The two researchers who carried out the experimental work; from left: Dr. I. Abdiaj (Janssen Research & Development, Spain), Dr. C. Bottecchia (Eindhoven University of Technology, The Netherlands)zoom
Trifluoromethylation of Highly Functionalized Heteroarenes: Flow to the Rescue
Timothy Nöel and Jesus Alcazar describe the trifluoromethylation of highly functionalized heteroarenes.
Visible-Light-Induced Trifluoromethylation of Highly Functionalized Arenes and Heteroarenes in Continuous Flow: I. Abdiaj, C. Bottecchia, J. Alcazar, T. Noёl Synthesis 2017, DOI: 10.1055/s-0036-1588527
The trifluoromethyl group is not present in nature but is widely present in synthetic drugs and bioactive compounds. For this reason, methods for incorporating this man-made, xenobiotic function into organic molecules continue to attract the interest of organic and medicinal chemists. The group of Professor Timothy Nöel, from the Eindhoven University of Technology (The Netherlands), in collaboration with the pharmaceutical company Janssen (Toledo, Spain), recently reported a new trifluoromethylation strategy induced by visible light and performed
Trifluoromethylation of highly functionalized heteroareneszoom
Professor Nöel said: “In our interest to develop a broadly applicable trifluoromethylation strategy for highly functionalized heteroarenes we envisioned a