From left: Prof. S. Dallavalle, Dr. R. Kaduskar, Dr. L. Musso (Università degli Studi di Milano, Italy)zoom
Synthesis of the Tripeptide Antibiotic Resormycin
Loana Musso presents the synthesis of the tripeptide antibiotic resormycin.
Synthesis of the Tripeptide Antibiotic Resormycin: R. D. Kaduskar, A. Pinto, L. Scaglioni, L. Musso, S. Dallavalle Synthesis 2017, DOI: 10.1055/s-0036-1588553
Resormycin is a tripeptide metabolite of bacterial origin that was shown to have remarkable antibiotic activity. Resormycin is also an interesting synthetic target owing to the presence of three unnatural and unusual α-amino acids. Recently, a group of researchers led by Dr. Loana Musso from the Università degli Studi di Milano (Italy), reported an efficient approach to resormycin, which can also be used for structure–activity relationship studies on this class of antibiotic peptides.
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