• Synthesis of Fused Naphthobenzofurans presented by Professor I. Kim, M. Nayak, D. K. Singh (Yonsei University, Incheon, South Korea)

    From left: M. Nayak, Professor I. Kim, D. K. Singh (Yonsei University, Incheon, South Korea)

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Sequential Sonogashira Coupling/Alkyne Carbonyl Metathesis for the Synthesis of Fused Naphthobenzofurans

Ikyon Kim presents a Sonogashira coupling/alkyne carbonyl metathesis leading to fused naphthobenzofurans.

Regiospecific Synthesis of 5- and 6-Acylated Naphtho[1,2-b]benzofurans via Intramolecular Alkyne Carbonyl Metathesis: M. Nayak, D. K. Singh, I. Kim
Synthesis 2017, 49, DOI: 10.1055/s-0036-1588120

Functionalized fused hetero-polyaromatic compounds are of great interest in materials science and chemical biology. Recently the group of Professor Ikyon Kim from Yonsei University (Incheon, South Korea) described an elegant synthesis of naphthobenzofurans having a carbonyl substituent in 6-position via C=C bond-forming cyclization involving an initial Sonogashira reaction.

  • Synthesis of fused naphthobenzofurans

    Synthesis of fused naphthobenzofurans

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Professor Kim said: 

“Intramolecular alkyne carbonyl metathesis was successfully utilized for the regiospecific synthesis of benzofuran-embedded polyaromatic heterocycles with an acyl moiety at the specific position.”

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