Connecting Remote C–H Bond Functionalization and Decarboxylative Coupling Using Simple Amines

R. Altman and P. H.-Y. Cheong report a novel methodology to decarboxylatively para-functionalize benzyl ester derivatives.

Regiocontrolled rearrangements taking place in high yields using experimentally simple conditions are key assets in the organic chemistry toolbox, especially if such processes result in the selective functionalization of unactivated C–H bonds. Recently, the groups of Professor Ryan A. Altman at The University of Kansas (USA) and Professor Paul Ha-Yeon Cheong at Oregon State University (USA) joined forces to investigate a novel methodology for achieving the decarboxylative para-functionalization of benzyl ester derivatives promoted by Pd catalysts and simple amine bases.

Read the full article Connecting Remote C–H Bond Functionalization and Decarboxylative Coupling Using Simple Amines

 

Get Trial Access to the chemistry journals
Download SYNFORM or read it online
Cookie-Einstellungen