Redox-Neutral Conversion of Ubiquitous PV Sources to a Versatile PO2+ Phosphorylation Reagent
Jan Weigand describes the synthesis of a versatile phosphorylation reagent from P(V) sources.
Phosphorus plays a pivotal role in organic and biological chemistry; furthermore, it is an essential element in several vitally important biological molecules, such as the nucleotides forming DNA and RNA biopolymers. In addition, phosphorus-containing molecules are endowed of countless applications, such as flame retardants, pharmaceuticals, food additives, pesticides, catalysts and many more. The production of most phosphorus-containing fine chemicals relies on the use of white phosphorus. Using white phosphorous in industrial production of phosphorus compounds generally makes use of white phosphorus (P4) involves the handling of environmentally hazardous bulk chemicals such as PCl3, PCl5 and OPCl3 (resulting from (oxy)chlorination reactions). It is therefore important to find novel, more sustainable methods for the synthesis of phosphorus-containing organic compounds, especially on a large scale.
This paper describes the efforts of Professor Jan Weigand at the Technische Universität Dresden (Germany) and co-workers in rethinking traditional synthetic schemes to produce phosphorus-containing chemicals.
Read the full article Redox-Neutral Conversion of Ubiquitous PV Sources to a Versatile PO2+ Phosphorylation Reagent
