Practical and Regioselective Amination of Arenes Using Alkyl Amines
Daniele Leonori describes the use of alkyl amines in the regioselective amination of arenes.
Anilines are organic molecules made of an aromatic and an amine component linked through a carbon–nitrogen bond. The formation of these bonds is among the top five reactions carried out globally and it is used to prepare widely prescribed medicines, agrochemicals and materials. In gener Daniele Leonori describes the use of alkyl amines in the regioselective amination of arenes.al, these high-value molecules are assembled using multi-step sequences where the aromatic component is pre-functionalized to enable the formation of the C–N bond.
Photoredox catalysis can offer new and more environmentally sustainable solutions to the problem of synthesizing complex organic compounds simply by harnessing the energy of light for promoting chemical reactions in the presence of a light-sensitive catalyst that can mediate electron transfers between readily available starting materials. In this recent paper, the group of Dr. Daniele Leonori at the University of Manchester (UK) has developed a new chemical method that assembles anilines by direct reaction of aromatic and alkyl amines upon blue light irradiation
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