Axially Chiral Bridged Biaryls by Ni-Catalyzed Kinetic Asymmetric C−O Bond Cleavage
Zhi-Chao Cao and Gen Luo developed a Ni-Catalyzed synthesis of axially chiral bridged biaryls.
Axially chiral bridged biaryl scaffolds, which represent an important subset of axial chirality in organic chemistry, have been acknowledged as a fundamental structural motif in many natural products, biologically active molecules, chiral ligands, and catalysts. Moreover, the unique torsional angle and electronic properties of this scaffold have greatly facilitated its widespread utilization in optoelectronic materials. “Enhancing the potential of catalytic methodologies for the enantioselective synthesis of axially chiral bridged biaryls is a significant objective within the realms of organic chemistry and medicinal chemistry, as well as materials science,” said Professor Zhi-Chao Cao at the Anhui Agricultural University (P. R. of China). In this work, the first example of a catalytic kinetic resolution through the asymmetric cleavage of an unactivated aromatic C–O bond was achieved, supported by DFT calculations carried out in the group of Professor Gen Luo at Anhui University (P. R. of China).
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