Modular Assembly of Acridines by Integrating Photo-Excitation of o-Alkyl Nitroarenes with Copper-Promoted Cascade Annulation
Yu-Mei Lin reports on a combination of photo-excitation and cascade annulation to synthesize various acridine derivatives.
Acridines play pivotal roles in natural products, pharmaceuticals, molecular probes, and optoelectronic devices. However, conventional synthetic methodologies often require the use of specialized starting materials, anaerobic and moisture-free procedures, as well as sequential multi-steps for disparate functional group installations. Recently, a research team led by Professor Yu-Mei Lin at Xiamen University (P. R. of China) has developed an innovative and modular approach to the synthesis of acridine derivatives, leveraging the synergistic combination of photo-excitation of o-alkyl nitroarenes with copper-mediated cascade annulation. Professor Lin explained that “this method significantly simplifies the synthesis of a diverse array of acridine compounds and expands the range of possible structures, including unsymmetric and multi-substituted derivatives.”
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