Insertion of Ammonia into Alkenes to Build Aromatic N-Heterocycles
Xu Cheng describes the synthesis of Aromatic N-Heterocycles from alkenes and ammonia.
Ammonia is one of the most-produced industrial chemicals, with a value of 144 million metric tons in 2020. In addition to its use in fertilizers, ammonia can also be utilized as a nitrogen source to build nitrogen-containing compounds. According to Professor Xu Cheng and Dr. Shuai Liu from Nanjing University (P. R. of China) there is a series of advantages when using ammonia as a nitrogen source, for example easy storage, transport, handling, and separation. Despite several challenges in pursuing applications of ammonia in organic synthesis (e.g., high bond dissociation energy or being a strong ligand for diverse metal species), the authors studied the direct insertion of ammonia into alkenes to build aromatic N-heterocycles with electricity as the driving force.
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