Deoxygenative Suzuki–Miyaura Arylation of Tertiary Alcohols through Silyl Ethers

Stephen Newman presents a Ni/Bi dual-catalyzed method for the Suzuki–Miyaura arylation of tertiary alcohols.

Suzuki–Miyaura cross-couplings are among the most utilized chemical reactions in the contemporary chemical industry, providing a rapid method for chemists to build molecular complexity. Professor Stephen Newman from the University of Ottawa (Canada) explains: “While this method of forming carbon–carbon bonds is practical; two notable limitations exist:
(1) The majority of Suzuki–Miyaura reactions feature the generation of biaryl link ages. The products are thus often flat molecules that lack the three-dimensional architecture that is common within bioactive molecules and natural products.
(2) Most Suzuki–Miyaura reactions use organo(pseudo)halides as electrophilic reaction partners. Such species are scarcely available in nature, often toxic/carcinogenic, and generate heavy metal–halide salts as waste products.”
His research group has a strong interest in this area of organic chemistry. Their aim is to solve problems by continuously pushing towards the development of methods that use naturally accessible substrates while generating the least amount of hazardous waste as possible.

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