Access to Unsaturated Bicyclic Lactones by Overriding Conventional C(sp3)–H Site Selectivity

Debabrata Maiti, with Haibo Ge and Xinglong Zhang, managed to override conventional C(sp3)–H site selectivity.

Bicyclic lactones are a privileged class of compounds that are ubiquitous in natural products and pharmacoactive molecules. The art of synthesizing such lactones in the most efficient ways has intrigued chemists for decades. Some of the popular methods utilized over the years are iodolactonization, intramolecular cyclization of hydroxy acids, and many more. Despite the popularity and success of these reactions, they are perhaps not the most effective strategies for making lactones or bicyclic lactones. Professor Debabrata Maiti from the Indian Institute of Technology Bombay (India) explained that with his group’s experience in C(sp3)–H activation, one of their long-standing goals was to simplify the synthesis of lactones or bicyclic lactones from aliphatic carboxylic acids in a single step.

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