• From left: Mao Yamaguchi, Professor Naoto Chatani and Takeshi Uemura (Osaka University, Japan)


Novel Route to Aromatic Hydrazines via Cu-Catalyzed Addition of Arylboronic Esters to Azodicarboxylates

Naoto Chatani discovered a novel route to aromatic hydrazines via Cu-catalyzed addition of arylboronic esters to azodicarboxylates.

Amination of Arylboronic Compounds via the Copper-Catalyzed Addition of Arylboronic Esters to Azodicarboxylates: N. Chatani and co-workers Synthesis 2015, DOI: 10.1055/s-0035-1560468

Aromatic amino compounds and derivatives, such as hydrazines, play a role of paramount importance in a number of vital sectors including pharmaceuticals, materials, dyes and agrochemicals. The development of effective synthetic approaches to these compounds continues therefore to represent an area of vibrant research in chemistry. Recently the group of Professor Naoto Chatani at Osaka University (Japan) has reported in SYNTHESIS a new simple and effective method for achieving the synthesis of aromatic hydrazines.

  • Amination of arylboronic esters

Professor Chatani said: “Not only arylboronic acids, but also arylboronic esters, which are readily soluble in common organic solvents, can be used in the new type of amination reaction of arylboronic compounds with di-tert-butyl azodicarboxylates in the presence of a copper catalyst under mild reaction conditions (room temperature).”
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