News-Archive 2020

11.12.2020 Scalable Synthesis of Thiazole Peptide Macrocycles

Dionicio Siegel describes the synthesis of the 26-membered core of thiopeptide natural products.

24.11.2020 Synthesis of Optically Active Maresin 2

Narihito Ogawa presents the synthesis of optically active maresins.

24.11.2020 Decarbonylative Alkynylation of Acyl Fluorides

Yasushi Nishihara presents the Ni-catalyzed decarbonylative alkynylation of acyl fluorides.

24.11.2020 First Total Synthesis of the Alkaloid Clausenalansine A

Hans-Joachim Knölker reports on the synthesis and structure of the alkaloid clausenalansine A.

23.11.2020 Synthesis of 4,5-Diaryl-2H-1,2,3-triazoles

Luyong Wu describes the synthesis of diaryltriazoles from tosylhydrazones and nitriles.

16.11.2020 Web Seminar on Select Crowd Review

On December 7, 2020, we hosted a virtual seminar on Select Crowd Review with talks by the founders of this review method. Read the highlights at a glance here!

09.11.2020 Poster Prize awarded at LatinXChem 2020

Daniella Cheang was awarded a Thieme Poster Prize at the virtual Twitter conference LatinXChem.

01.11.2020 HAPPY BIRTHDAY, SOS!

We celebrate the 20th birthday of Science of Synthesis. Join us and enjoy 36 articles throughout the year by top chemists to honor the anniversary!

20.10.2020 Diastereoselective Total Synthesis of (±)-Parvistemonine A

Kazuyuki Sugita reports on the total synthesis of (±)-parvistemonine A.

sos virtual symposium SOS Symposium in Honor of Barry Trost

On November 11, 2020, our virtual SOS symposium with talks by Barry Trost and some of his alumni took place. Read the highlights at a glance here!

19.10.2020 Synthesis of Thienyl Thioethers and Thieno[3,2-b]thiophenes

Koichi Mitsudo and Seiji Suga show the integrated synthesis of the title compounds via 1-benzothiophen-3(2H)-ones.

19.10.2020 Synthesis of an Azabicyclo[3.1.0]hexanone Drug Candidate

James Crawford describes the synthesis of an azabicyclo[3.1.0]hexanone-containing NIK inhibitor.

19.10.2020 Redox-Neutral C1-Alkynylation of Tetrahydroisoquinolines

Vladimir Kouznetsov presents a comparative study between visible light photocatalysis and transition-metal catalysis.

21.09.2020 Synthesis of Secondary Alcohols from Alkynes in Water

Renshi Luo describes the efficient hydration and tandem transfer hydrogenation of alkynes.

21.09.2020 Synthesis of Fused-ring Heptacyclic Pyrrolidines

Issa Yavari presents the synthesis of heptacyclic pyrrolidines via 1,3-dipolar cycloadditions.

16.09.2020 Peptide Synthesis with α,α-Difluoro-β-Lactams

Masaaki Omote describes a peptide synthesis via one-pot ring opening.

15.09.2020 Synthesis of 13,19,20-Trihydroxy Docosahexaenoic Acid Stereoisomers

Narihito Ogawa presents two stereoisomers of a trihydroxy derivative of docosahexaenoic acid.

14.09.2020 Propargylation of Diaryl Azo Compounds

Akira Yanagisawa uses metallic barium for the propargylation of diaryl azo compounds.

Thieme and Science of Synthesis are supporting LatinXChem 01.09.2020 Thieme and Science of Synthesis are now supporting LatinXChem Poster Conference

This online event is taking place on September 7, 2020. Find out more on latinxchem.org.

Select Crowd Review 28.07.2020 Select Crowd Review is shortlisted for the 2020 ALPSP Awards for Innovation in Publishing

Select Crowd Review offers secure, fast and substantive reviewing in today’s fast-moving scientific world. Now it's shortlisted for the 2020 ALPSP Awards for Innovation in Publishing.

Professor Steven Diver 27.07.2020 Science of Synthesis Knowledge Updates – New Volume Editor

Welcoming Professor Steven Diver to the Science of Synthesis Editor Team!

Case Study: Alexander Preinfalk, Institute of Organic Chemistry, University of Vienna 22.07.2020 Case Study: Enantioconvergent Cross-Coupling of Racemic Secondary Organozinc Reagents

Alexander Preinfalk, Institute of Organic Chemistry, University of Vienna.

SOS virtual roadshow 15.07.2020 SOS Virtual Roadshow

Join Dr. Karen Muirhead-Hofmann and Dr. Toby Reeve in this virtual SoS Roadshow to find out how to use SoS for your research. Time: July 21, 3:00 p.m. CEST. This online event is open to all.

Women in Chemistry Award 2021 01.07.2020 Women in Chemistry Award 2021

Call for Nominations: Thieme Chemistry and the Editors of Science of Synthesis announce the Margaret Faul Women in Chemistry Prize 2021.

Professor Guosheng Liu 30.06.2020 Science of Synthesis Knowledge Updates – New Volume Editor

Professor Guosheng Liu was appointed as Volume Editor for SOS Volume 47, Alkenes.

29.06.2020 Total Synthesis of Phyllanemblinin B

Shinnosuke Wakamori presents the total synthesis of phyllanemblinin B.

09.06.2020 Synthesis and Structure of 1-Substituted Semithioglycolurils

Vladimir Baranov presents the synthesis and structure of 1-substituted semithioglycolurils.

05.06.2020 Copper-Catalyzed Stereoselective Synthesis of 2-Deoxygalactosides

Jianbo Zhang describes a new stereoselective approach to 2-deoxygalactosides.

Case Study – Thomas Duhamel 03.06.2020 Case Study: C(sp3)-H Amination for Pyrrolidine Synthesis

Thomas Duhamel, Institute of Chemical Research of Catalonia (ICIQ), Tarragona, Spain.

  Professor Jahanne G. de Vries 25.05.2020 Science of Synthesis Knowledge Updates – New Volume Editor

Professor Johannes de Vries appointed as Volume Editor for SOS Volume 25, Aldehydes

Science of Synthesis – Dual Catalysis in Organic Synthesis 23.05.2020 Dual Catalysis in Organic Synthesis

Dual catalysis has developed rapidly over the last decade, and these volumes highlight the application of synergistic and cooperative dual catalysis as a means of efficiently increasing molecular complexity.

Science of Synthesis – Advances in Organoboron Chemistry towards Organic Synthesis 23.05.2020 Advances in Organoboron Chemistry towards Organic Synthesis

This SOS volume provides a collection of the most useful, practical, and reliable methods for advanced borylation reactions.

APIs COVID-19 22.05.2020 15 APIs of interest in COVID-19 treatment

Recently, there have been many reports of investigations into the repurposing of currently available drugs as potentially effective treatments for the novel coronavirus disease COVID-19. We provide free PDFs from Pharmaceutical Substances.

19.05.2020 Synthesis of Alkyl-methyl/ethyl Derivatives from N-(Acyloxyalkyl)phthalimides

Rui Shang shows the cobalt-catalyzed decarboxylative methylation and ethylation of N-(acyloxy)phthalimides.

19.05.2020 Synthesis of N-Substituted Ureas from Primary Amides

Vincent Reboul describes a direct and convenient approach to N-substituted ureas.

Professor Zheng Huang 11.05.2020 Science of Synthesis Knowledge Updates – New Volume Editor

Professor Zheng Huang to be Volume Editor for SOS Volume 48: Alkanes

04.05.2020 Regioselective Synthesis of 3,5-Disubstituted Pyrazoles

Virginie Ratovelomanana-Vidal shows the synthesis of 3,5-disubstituted pyrazoles from bromovinyl acetals and N-tosylhydrazones.

04.05.2020 Synthesis of Hybrid Chromone/Coumarin 3-Halo-1H-indenes

Rodney A. Fernandes presents the synthesis of 3-halo-1H-indenes via cascade halo-Nazarov-type cyclization.

04.05.2020 Annulation Approach to Tetrahydro-1,2,4-triazinecarboxylate Esters

Jun-An Ma describes the silver-catalyzed [3+3] annulation of glycine imino esters.

SOS 28.04.2020 The Science of Synthesis Advisory Board Welcomes New Members

Professor J. Goodman (University of Cambridge), Dr. Y. Li (MIT), and Dr. D. Wrublewski (Caltech).

Professor Stephen Marsden 28.04.2020 Science of Synthesis Knowledge Updates – New Volume Editor

Professor Stephen Marsden to be Volume Editor for updating of SOS Volume 26: Ketones.

Case Study: University Graz – Alexander Pöcheim 28.04.2020 Case Study: Identifying Suitable Strategies for Silole Synthesis

Alexander Pöcheim, Graz University of Technology, Institute of Inorganic Chemistry, Austria

17.04.2020 Scalable Synthesis of Sphingomyelins

Nicolas Philippe and Serge Pérard present the synthesis of sphingomyelins.

17.04.2020 Synthesis of Polycyclic Indolines

Farnaz Jafarpour demonstrates a new application of palladium/norbornene chemistry.

17.04.2020 Diels–Alder Based Approach to Prenyleudesmane Diterpenoids

Hiroaki Miyaoka describes a concise total synthesis of sunipol.

30.03.2020 Birthday wishes for Science of Synthesis

We celebrate the 20th birthday of SoS. On this occasion we received many birthday wishes.

25.03.2020 Total Synthesis of Glycosyl Flavonoids

Venkateswara Rao Batchu presents the total synthesis of glycosyl flavonoids.

25.03.2020 Total Synthesis of Asparenydiol

Gaetano Angelici and Claudio Evangelisti describe the total synthesis of asparenydiol by cross-couplings.

24.03.2020 Synthesis of the Enantiomers of Thioridazine

Simen Antonsen used an auxiliary-based strategy to synthesize the enantiomers of thioridazine.

18.03.2020 Novel Synthesis of Benzoxazoles and Benzimidazoles

P. H. Tran shows the S/DABCO-promoted reaction of o-hydroxy/amino nitrobenzenes and benzaldehydes.

18.03.2020 A Study of Samarium(II)–Water Allylic Benzoate Reductions

Gregory O’Neil reports on effects of various directing groups on allylic benzoate reductions.

16.03.2020 Formal Synthesis of Pseudolaric Acid B

Naoki Mori presents a formal synthesis of pseudolaric acid B.

16.03.2020 Metal-Free Synthesis of Hindered 3-Azoindoles

Joanna Wencel-Delord describes the synthesis of hindered 3-azoindoles via C–H functionalization.

Professor Chao-Jun Li 12.02.2020 Science of Synthesis Knowledge Updates – New Volume Editor

Professor Chao-Jun Li joins the SOS Volume Editor Team.

11.02.2020 Deoxofluorination of β-Keto Esters with Sulfur Tetrafluoride

Dmitriy Volochnyuk and Sergey Ryabukhin take a close look at safety vs efficacy issues in the fluorination of β-keto esters.

11.02.2020 A Radical-Chemistry Approach to 2-Arylquinolines

Hideo Togo presents the synthesis of 2-arylquinolines from 2-arylethyl bromides and aromatic nitriles.

Professor Jean-Luc Montchamp 29.01.2020 Science of Synthesis Knowledge Updates – New Volume Editor

Professor Jean-Luc Montchamp is new Volume Editor for SOS Organophosphorus Updates.

21.01.2020 Novel 2-Substituted Analogues of (–)-Pentenomycin I

Christos Stathakis and Anna Hirsch present novel 2-substituted analogues of (–)-pentenomycin I.

21.01.2020 Detailed Comparison of Ni vs. Pd in Cross-Coupling Catalysis

David Nelson investigates the role of substrate coordination to zerovalent metal complexes.

Professor Alexander Terent'ev 15.01.2020 Science of Synthesis Knowledge Updates – New Volume Editor

Prof. Alexander O. Terent’ev Appointed as Volume Editor for SOS Volume 38: Peroxides.

08.01.2020 SYNTHESIS welcomes a new editor!

Prof. Liu-Zhu Gong from the University of Science and Technology of China has joined the Editorial Board of SYNTHESIS

07.01.2020 Synthesis of Sulfonylisoureas via Sulfo-Click Reactions

Stefan Kirsch presents a new method for the synthesis of sulfonylisoureas.

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