• Rylan Lundgren presents a copper-mediated synthesis of monofluoro aryl acetates.

    From left: Prof. R. J. Lundgren, A. Fahandej-Sadi (University of Alberta, Edmonton, Canada)

      zoom

Monofluoro Aryl Acetates via Copper Catalysis

Rylan Lundgren presents a copper-mediated synthesis of monofluoro aryl acetates.

Copper-Mediated Synthesis of Monofluoro Aryl Acetates via Decarboxylative Cross-Coupling: A. Fahandej-Sadi, R. J. Lundgren Synlett 2017, DOI: 10.1055/s-0036-1588516


Man-made, synthetic fluorinated molecules continue to play a prominent role as drugs, agrochemicals, materials and much more. Fluoro-aryl acetic acid derivatives are important building blocks in fluoroorganic chemistry and feature a range of interesting biological activities. Professor Rylan J. Lundgren from the University of Alberta (Edmonton, Canada) has recently reported a new approach the the synthesis of the title compounds.

  • Rylan Lundgren presents a copper-mediated synthesis of monofluoro aryl acetates.

    Monofluoro aryl acetates via copper catalysis

      zoom
Professor Lundgren said: “By utilizing a Cu-promoted oxidative cross-coupling reaction with simple, readily available monofluorinated building blocks, we have devised a way to prepare monofluoro α-aryl acetates, under air at room temperature, with substrates bearing functional groups that are not easily tolerated by existing arylation methods.”
Get Trial Access to the chemistry journals
Download SYNFORM or read it online
Cookie-Einstellungen