Total Synthesis of (–)-Haouamine B Pentaacetate

Haouamines A and B are structurally unique alkaloids possessing strong cytotoxicity against the HT-29 human colon carcinoma cell line. While both haouamines had been synthesized before, Professor Hidetoshi Tokuyama and his group successfully completed the ‘haouamine saga’ by synthesizing haouamine pentaacetate B and confirmed its absolute configuration.

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