Synthesis of Chiral Heterocyclic Sulfoxides
Sulfoxides of high stereochemical purity are widely used in organic synthesis as organocatalysts, ligands, and chiral auxiliaries. Molecules incorporating a sulfinyl group are also important in medicinal chemistry, as witnessed by the presence on the market of important drugs such as esomeprazole, armodafinil, and sulindac, which belong to the sulfoxide family. By developing new, efficient catalysts (fully alkylated bicyclic guanidines) Choon-Hong Tan’s group was able to synthesize chiral heterocyclic sulfoxides.
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