Expedient Synthesis of Highly Functionalized Cyclic Imines

Cyclic imines are very important building blocks in organic chemistry, and this is particularly true for cyclic imines fused with aromatic rings. Although a number of methods are available for accessing these scaffolds, most of them are affected by significant weaknesses including low regiochemical control, substrate limitations, and harsh reactions conditions. For these reasons, the development of straightforward and efficient methods for preparing cyclic imines incorporating aromatic rings remains an active area of research in organic synthesis. Recently, Dr. Thomas A. Moss from AstraZeneca Mereside (UK) reported a new efficient route for producing highly functionalized cyclic imines.

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