Creation of Acyclic All-Carbon Quaternary Stereocenters

Asymmetric α-alkylation of carbonyl compounds is one of the fundamental C–C bond-forming reactions in forging a carbon stereogenic center, particularly for constructing acyclic all-carbon quaternary stereogenic centers, which remains a significant challenge in asymmetric catalysis and synthesis in spite of the tremendous advances in this field. Professor Sanzhong Luo and his group (ICCAS, Beijing, P. R. of China) report the construction of acyclic all-carbon quaternary stereocenters using an open-shell radical substitution strategy by invoking the synergy of photoredox catalysis and primary amine catalysis.

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