CpRu-Catalyzed Carbene Insertions into Epoxides: 1,4-Dioxene Synthesis via SN1-like Chemistry with Retention

The group of Professor Jérôme Lacour at the University of Geneva (Switzerland) has recently reported a series of original transformations, using cyclic ethers as substrates, α-diazo-β-keto esters as reagents and rhodium/ruthenium catalysts for the diazo decomposition, that are best rationalized by the successive formation of metal carbenes and oxonium ylide intermediates.

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