Asymmetric Total Synthesis of (+)-trans-Dihydrolycoricidine

The group of Professor James McNulty at McMaster University in Hamilton (Ontario, Canada) has recently reported a short, asymmetric total synthesis of the anticancer amaryllidaceae alkaloid (+)-trans-dihydrolycoricidine. Interest in the isolation, structure, biosynthesis, total synthesis and biological evaluation of amaryllidaceae constituents continues unabated due to their potent nanomolar anticancer activities.

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