Asymmetric C–H Functionalization of Cyclopropanes

Since their original discovery, powerful bidentate directing groups such as 8-aminoquinoline and picolinamide auxiliaries have been widely used for the activation of both C(sp2)–H and C(sp3)–H bonds. In order to improve convenience and efficiency of the method, the development of new types of bidentate directing groups has been the subject of intensive research involving many groups. Despite the impressive achievements in catalytic asymmetric C–H activation through installation of chiral auxiliary, stereoselective functionalization of C(sp3)–H bonds controlled by chiral bidentate directing groups still remains elusive. The laboratory of Professor Sungwoo Hong at the Korea Advanced Institute of Science and Technology (KAIST, Daejeon, Korea) has been particularly interested in selective C–H functionalization of medicinally important privileged structures.

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