From left: Prof. M. Pohmakotr, N. M. Betterley, Prof. C. Kuhakarn, Prof. D. Soorukram, S. Chaturonrutsamee, Prof. V. Reutrakul (Mahidol University, Bangkok, Thailand)zoom
Difluoro(phenylsulfanyl)methane as a Formylating Agent
Electrophilic Aromatic Formylation with Difluoro(phenylsulfanyl)methane: N. M. Betterley, S. Kongsriprapan, S. Chaturonrutsamee, P. Deelertpaiboon, P. Surawatanawong, M. Pohmakotr, D. Soorukram, V. Reutrakul, C. Kuhakarn
Synthesis 2018, DOI: 10.1055/s-0036-1591545
Although the C–F bond is exceptionally stable, fluoroalkyl reagents can sometimes be used in non-orthodox ways by inducing loss of fluoride, which is also exceptionally stable. One such example was recently published by the group of Professor Chutima Kuhakarn from Mahidol University (Bangkok, Thailand) for the synthesis of differently substituted benzaldehydes. The process is mediated by SnCl4 which was used as Lewis acid for promoting defluorination.
Formylation with Difluoro(phenylsulfanyl)methanezoom