Asymmetric Synthesis of Tetrazole and Dihydroisoquinoline Derivatives by Isocyanide-Based Multicomponent Reactions

Xiaoming Feng shows an application of isocyanide-based multicomponent reactions.

Isocyanide-based multicomponent reactions (IMCRs), which enable the diversity- and complexity-oriented synthesis of collections of compounds taking advantage of the unique reactivity of the isocyanide functionality, have attracted great interest in the past several decades. In particular, the Passerini and Ugi reactions, and their variants, provide facile and powerful methods for the rapid construction of α-acyloxy carboxamides and α-acetamido carboxamides, as well as many heterocycles. Professor Xiaoming Feng at Sichuan University (P. R. of China) pointed out that enantioselective versions of these types of reactions, which are seemingly simple and yet challenging, have been recently achieved by several research groups after extensive studies.

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