Acceptorless Dehydrogenative Coupling Using Ammonia: Direct Synthesis of N-Heteroaromatics from Diols Catalyzed by Ruthenium
David Milstein presents the direct, Ru-catalyzed synthesis of N-heteroaromatics from diols.
Acceptorless dehydrogenative coupling (ADC) reactions involve dehydrogenation, with generation of hydrogen gas, of various substrates, followed by coupling of the dehydrogenated intermediate with another substrate to form a value-added product. Many of these reactions form the basis for efficient, sustainable and environmentally benign (‘green’) synthetic methodologies. The group of Professor David Milstein at the Weizman Institute of Science (Rehovot, Israel) focuses on the design and development of ADC reactions for green organic transformations catalyzed by special pincer-based metal complexes.