A Biomimetic Synthesis of des-Hydroxy Paecilospirone
A Biomimetic Synthesis of des-Hydroxy Paecilospirone: Z.-G. Feng, G. L. Burnett, T. R. R. Pettus
Synlett 2018, DOI: 10.1055/s-0036-1592001
Paecilospirone is a spiro[chroman-2,1′(3′H)-isobenzofuran], first collected from the marine fungus Paecilomyces sp. near Yap Island, that was reported to inhibit microtubule assembly. A total synthesis of (+)-paecilospirone in 19 steps was reported in 2011. Recently, the group of Professor Thomas R. R. Pettus from University of California (Santa Barbara, USA) reported a new bio-inspired approach to the title compound. The synthesis is de facto based on the dimerization of a single precursor molecule derived from 3-hydroxybenzoic acid.