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Free-Radical and Protecting-Group-Free Synthesis of (–)-Boschnialactone and γ-Lycorane

A Free-Radical and Protecting-Group-Free Approach to (–)-Boschnialactone and γ-Lycorane: A. Basante-Avendaño, V. E. Guerra-Ayala, A. Sánchez-Eleuterio, A. Cordero-Vargas
Synthesis 2019, DOI: 10.1055/s-0037-1612248

The development of synthetic strategies that circumvent the use of environmentally and economically incompatible protecting groups is one of the main priorities of modern organic synthesis. Free-radical reactions are particularly attractive for pursuing this goal. In this context, Professor Alejandro Cordero-Vargas and co-workers from the Universidad Nacional Autónoma de México (Mexico City, Mexico) recently described a versatile approach to two natural products, (–)-boschnialactone and γ-lycorane. 

  • Synthesis of (–)-boschnialactone and γ-lycorane

     

Professor Cordero-Vargas said: “This article represents an important application of the previously developed methods concerning radical-ionic sequences, and also showcases the great compatibility between free-radical reactions and protecting-group free synthesis.” 

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