From left: Dr. E. Damen, J. A. Dekker, Dr. R. N. S. van der Haas (Mercachem Process Research B.V., Nijmegen, The Netherlands)
Synthesis of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts
Richard van der Haas describes the synthesis and properties of 2-oxa-6-azaspiro[3.3]heptane sulfonate salts.
Synthesis and Properties of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts: R. N. S. van der Haas, J. A. Dekker, J.
Synthesis 2017, 49, DOI: 10.1055/s-0036-1588733
Highly reactive and strained heterocycles are of great interest as building blocks in synthetic organic chemistry and drug discovery. One such unit that has attracted recent interest is the 2-oxa-6-azaspiro[3.3]heptane unit, which has been proposed as a surrogate for morpholine in drug-like compounds and whose synthesis has been shown to be challenging. Recently, the group of Dr. Richard N. S. van der Haas at the company
Dr. van der Haas said: “With this well-scalable approach 2-oxa-6-azaspiro[3,3]heptane is finally available as a stable, crystalline, well-defined and more soluble sulfonate salt ready for use in chemical conversions.”