Synthesis of Calixarene Appended Lactosylated G1 and Galactosylated G2 Generation Glycodendrimers Using a ‘CuAAC’ Click Approach
Vinod K. Tiwari presents a ‘CuAAC’ Click approach to build calixarene-cored (ga)lactosylated G1 and G2 glycodendrimers.
Bioconjugate chemistry is an expanding area of research at the interface between chemistry and biology that is attracting enormous and still-increasing interest. The group of Professor Vinod K. Tiwari at Banaras Hindu University (India) has been interested in the use of carbohydrates in bioconjugate chemistry. Considering the widespread applications of click chemistry, the biocompatible nature and manifold importance of glycodendrimers and the group’s previous experience in click chemistry for glycodendrimer synthesis, Professor Tiwari and co-workers decided to explore a regioselective and modular CuAAC ‘Click Chemistry’ tool and recently reported a convenient synthesis of a class of calixarene-cored lactosylated G1 and galactosylated G2 glycodendrimers from commercially available sugars, by utilizing a convergent route.