Rhodium-Catalyzed Atroposelective C–H Arylation: Efficient Synthesis of Axially Chiral Heterobiaryls

Shu-Li You describes an efficient, Rh-catalyzed synthesis of axially chiral heterobiaryls.

Axially chiral biaryls are important scaffolds that exist widely in natural products and pharmaceuticals and are also utilized as privileged ligands and catalysts in asymmetric synthesis. Thus, the development of novel methods for the efficient asymmetric synthesis of axially chiral biaryls, enabled by transition-metal catalysis or organocatalysis, has attracted enormous interest in the chemical community. The group of Professor Shu-Li You from the Shanghai Institute of Organic Chemistry (SIOC, P. R. of China) has been interested in the synthesis of axially or planar chiral molecules through transition-metal-catalyzed asymmetric C–H functionalization reactions for some time.
Recently, Professor You and his group developed an efficient method for facile synthesis of axially chiral heterobiaryls with high enantioselectivities via atroposelective C–H arylation reactions.

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