Synthesis of Fused-Ring Heptacyclic Pyrrolidines via 1,3-Dipolar Cycloadditions
Regio- and Stereoselectivity in the 1,3-Dipolar Cycloaddition Reactions of Isoquinolinium Ylides with Cyclopenta[a]acenaphthylen-8-ones: I. Yavari, P. Ravaghi, M. Safaei, J. Kayanian
Complex fused-ring polycyclic compounds are particularly interesting as functional molecular tools as well as building blocks in materials science. A straightforward approach to highly complex and functionalized fused-ring heterocyclic derivatives has been recently reported by the group of Professor Issa Yavari from Tarbiat Modares University (Tehran, Iran), who exploited a 1,3-dipolar cycloaddition reaction between tetracyclic cyclopentadienones and isoquinolinium N-ylides stabilized by aryl-carbonyl groups.
Professor Yavari said: “A regio- and diastereoselective synthesis of functionalized heptacyclic pyrrolo[2,1-a]isoquinolines via a nonconcerted mechanism has been developed.”