One-Pot Access to 2-Aryl-3-(arylmethyl)chromones

One-Pot Access to 2-Aryl-3-(arylmethyl)chromones: M.-Y. Chang, K.-T. Chen, Y.-L. Tsai, H.-Y. Chen
Synthesis 2019, DOI: 10.1055/s-0039-1690760


Flavone and homoisoflavanone are widely present in natural products and serve as multifunctionalized blocks in synthetic organic chemistry. Interestingly, they exhibit diverse bioactive properties, including antioxidant, anticancer, and antimicrobial activity. 2-Aryl-3-(arylmethyl)chromone is considered a chimera of flavone and homoisoflavanone. Recently, the group of Dr. Meng-Yang Chang from Kaohsiung Medical University (Taiwan) reported a one-pot access to the title structural scaffold.


Dr. Chang said: “In the article, we have developed a facile-operational NaOH-controlled synthesis of
2-aryl-3-arylmethylchromones via intermolecular double-aldol condensation of o-hydroxyacetophenones with two equivalents of aryl aldehydes under warming MeOH reaction conditions in moderate to good yields.”

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