SYNLETT Best Paper Award 2020: New Musks and the Molecular Modeling of Olfactory Receptors
P. Kraft, S. Riniker and Q. Wang tell the story behind their award-winning paper on a new family of rigid dienone musks.
The award-winning article deals with how a new family of rigid dienone musks challenges the perceptive range of the human olfactory receptor OR5AN1. The work is a joint effort of the groups of Dr. Philip Kraft (Givaudan Innovation Center Kemptthal, Switzerland), Professor Sereina Riniker (ETH Zurich, Switzerland) and Professor Quanrui Wang (Fudan University, P. R. of China). The authors report on the current challenges in fragrance research to provide sustainable, renewable, and biodegradable ingredients and how new receptor assays to generate activity data beyond odor thresholds helped in the project. The collaboration also was an excellent opportunity to assess the state-of-the-art computational approaches for odor receptor modeling in a prospective real-world setting. It expanded the family of synthetic musks and provided new insights into the molecular mechanisms by which this special scent is produced.