Ozonolysis of Alkynes – A Flexible Route to α-Diketones. Synthesis of AI-2
George Kraus presents ozonolysis of alkynes as a convenient entry to α-diketones.
α-Diketones are useful substrates in the preparation of heterocyclic compounds and have a number of other applications in organic synthesis. Alkynes can be oxidized to α-diketones using a range of different experimental conditions, but all these methods invariably make use of metals such as ruthenium, permanganate or mercuric salts. A more flexible, environmentally friendly and economic conversion of alkynes into α-diketones would represent a breakthrough in the preparation of these compounds.
Professors Larry Halverson and George Kraus from Iowa State University (Ames, USA) are part of an interdisciplinary team supported by the US Department of Energy for developing an instrument to detect and quantify microbial metabolites and plant proteins secreted into the soil surrounding plant roots. Recently, their group has identified ozonolysis of alkynes as a highly convenient and versatile entry to structurally diverse α-diketones.
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