Enantioselective Copper-Catalyzed sp2/sp3 Diborylation of 1‑Chloro-1-trifluoromethylalkenes

Qiuling Song describes the Cu-catalyzed sp2/sp3 diborylation of 1chloro-1-trifluoromethylalkenes.

As one of the most important classes of molecules, organoboron compounds have been widely used in organic synthesis, and the introduction of fluorine-containing groups in these structures can efficiently control their physical, chemical, and biological properties. Therefore, fluorine-containing organoboron compounds are widely recognized as a very prominent class of synthons, which find countless applications in organic synthesis, but still have enormous potential for more. Among them, fluorine-containing compounds with chemically different C–B bonds are particularly attractive, because these C–B bonds can undergo chemoselective and diverse transformations to form controllable and multifunctional complex target molecules. Professor Qiuling Song’s group from Fuzhou University (P. R. of China), investigated on the interesting and challenging synthesis of organic fluorine-containing asymmetric diboron compounds.

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