Asymmetric Remote C–H Borylation of Aliphatic Amides and Esters with a Modular Iridium Catalyst
Masaya Sawamura presents the Ir-catalyzed asymmetric C–H borylation of aliphatic amides and esters.
Aliphatic carboxylic acids and their derivatives such as amides, esters and the longer-chain fatty acids are widely distributed and abundant in nature, with their paramount importance prominently reflected in a variety of natural products, bioactive molecules and pharmacologically relevant compounds. Professor Masaya Sawamura from Hokkaido University (Sapporo, Japan) explains that these renewable biomass resources are attractive precursors to produce industrially significant materials, including plastics, as well as for the synthesis of drugs and other therapeutically important compounds.
While the direct and selective activation of C–H bonds in these raw materials represents a more environmentally friendly and step-economic process, current strategies are limited to the functionalization of proximal C–H bonds located one or two carbons away (α or β) from the carbonyl group.