• From left: Prof. Munetaka Akita, Prof. Takashi Koike (Tokyo Institute of Technology, Japan)


Photoredox Catalysis for a Novel Access to Pentafluorosulfanyl Compounds

Takashi Koike and Munetaka Akita report the photoredox catalysis for a novel method to access pentafluorosulfanyl compounds.

Radical Pentafluorosulfanylphenylation of Styrenes by Photoredox Catalysis: Y. Li, T. Koike, M. Akita
Synlett 2016, DOI: 10.1055/s-0035-1561304
Pentafluorosulfanyl (SF5) compounds are increasingly pursued as novel drug candidates, agrochemicals and various bioactive compounds. However, introduction of the ‘super-trifluoromethyl’ – as it is often dubbed – the SF5 group remains a challenging synthetic endeavor despite significant recent progress in the area. Professors Munetaka Akita and Takashi Koike from the Tokyo Institute of Technology (Japan) have recently reported a very interesting novel strategy based on the introduction of
SF5 -substituted aromatic radicals onto styrene scaffolds via photoredox catalysis with ruthenium.
  • Radical Pentafluorosulfanylphenylation of Styrenes by Photoredox Catalysis

Professor Akita said: “Photoredox-catalyzed radical pentafluorosulfanylphenylation allows us to easily access a variety of compounds containing SF5, which is a useful and promising structural motif in biologically active molecules and organic functional materials.”
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