Pd-Catalyzed Synthesis of ortho-Fluorodiarylmethanes
Ryoichi Kuwano presents the palladium-catalyzed synthesis of ortho-fluorodiarylmethanes.
Palladium-Catalyzed Decarboxylation of Benzyl Fluorobenzoates: Y. Makida, Y. Matsumoto, R. Kuwano
Synlett 2017, DOI: 10.1055/s-0036-1588572
Fluorine is a small atom with a big ego, according to the famous definition of the late Professor Kenji Uneyama (Okayama University, Japan), and its chemistry is unique and sometimes unpredictable. Another example of the peculiar properties of fluorinated compounds has been discovered recently by the group of Professor Ryoichi Kuwano from Kyushu University (Fukuoka, Japan). In the paper the authors demonstrate that a novel palladium-catalyzed decarboxylative cross-coupling reaction requires an ortho-fluorine atom – and the steric constraint on another substituent in ortho-position – to result in a new C–C bond formation.