Myoglobin-Catalyzed Olefination of Aldehydes
Biocatalytic processes are widely used by pharmaceutical companies for synthesizing small-molecule drugs and intermediates. Biocatalysis is currently of enormous interest both in academia and industry for its capacity to produce a wide range of chemicals under more environmentally and economically sustainable conditions. Recently, Professor Rudi Fasan’s group at the University of Rochester (USA) reported the first example of a biocatalytic aldehyde olefination. Essentially, the authors demonstrated that engineered active-site variants of myoglobin constitute efficient catalysts for the conversion of aryl aldehydes into olefins in the presence of α-diazo esters and triphenylphosphine or triphenylarsine.
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