Enantioselective Synthesis of P-Stereogenic Compounds

Chiral phosphine compounds are extremely useful ligands in catalysis. However, phosphorus (P)-chiral ligands have not been explored as extensively in catalytic reactions as axially chiral, carbon (C)-chiral, or planar-chiral compounds such as binap, diop, or josiphos. Asymmetric catalysis has the potential to provide a more direct and efficient synthetic route compared to traditional resolution methods of constructing P-chiral compounds. C–H bond functionalization has been an extremely popular topic over the past decade, and numerous methods based on a C–H bond activation strategy have been developed to build diverse complex molecules from unfunctionalized materials. The group of Professor Wei-Liang Duan at the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (P. R. of China) now present their research regarding the enantioselective C–H arylation strategy for the synthesis of useful P-stereogenic compounds.


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