From left: Florent Blanchard, Dr. Géraldine Masson, and Clément Lebée (ICSN, Gif-sur-Yvette, France)
Enantioselective Intermolecular Iodo- and Chloroamination of Enecarbamates
Geraldine Masson reports on the enantioselective intermolecular iodo- and chloroamination of enecarbamates.
Highly Enantioselective Intermolecular Iodo- and Chloroamination of Enecarbamates Catalyzed by Chiral Phosphoric Acids or Calcium Phosphate Salts: G. Masson and co-workers
Synlett 2016, DOI: 10.1055/s-0035-1650585
α,β-Haloamines are useful synthetic intermediates in organic synthesis for the preparation of biologically important compounds and drugs. One of the most direct entries to α,β-haloamines is the vicinal haloamination of a C=C bond. Notwithstanding the fact that the enantioselective version of this reaction has recently been the object of significant research efforts, it remains a challenging transformation to achieve. Recently, Dr. Géraldine Masson and co-workers from the ICSN and UPS (Gif-sur-Yvette, France) reported a new synthetic approach to α,β-haloamines.
Dr. Masson said: “Phosphoric acids and chiral calcium phosphates both catalyze the highly enantio- and diastereoselective chloro- and iodoamination of enecarbamates to provide an atom-economical synthesis of enantioenriched vicinal haloamines.”