Developing the Chemistry of Boroles to Access Larger Boracycles

Caleb Martin presents the synthesis of larger boracycles starting from boroles.

Boron heterocycles are emerging as an attractive class of molecules due to their promise in pharmaceuticals and electronic materials. The first drug containing a boron heterocycle approved by the US FDA was tavaborole in 2014 for the treatment of onychomycosis, a nail fungus. According to Professor Caleb Martin from Baylor University (Waco, Texas, USA) “when the vacant orbital on boron is in conjugation with an unsaturated system it lowers the energy of the π* orbital in the molecule, often resulting in properties desirable for organic light emitting diodes (OLEDs) and organic photovoltaic devices (OPVs),” leading to applications in electronic materials. He continued: “Despite the utility of boron heterocycles, there remain challenges in accessing tricoordinate species due to their propensity to form undesirable four­coordinate compounds when nucleophiles are added.” His research group now used boroles to access boron heterocycles.

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