Current SynOpen Highlights

SynOpen is an international open access journal reporting current research results in chemical synthesis in full paper, letter and review format. We present you today a few new features:

  • SynOpen generally uses Select Crowd Review for reviewing manuscripts 
  • Authors have the possibility to opt for double-blind review in connection with select crowd review.
  • SynOpen offers now the option to submit Spotlights, which highlight the preparation and uses of selected reagents and methods in current research.

Please see the latest example:

Hedouin, Gaspard; Dherbassy, Quentin; Wencel-Delord, Joanna; Colobert, Françoise:
An Improvement of the Synthesis of (1R,2S,5R)-(–)-Menthyl (S)-p-Toluenesulfinate

If you are interested to submit a Spotlight, please first contact Editor-in-Chief Prof. Laurence M. Harwood.


Moreover, we recommed these two highlights: 

Development of a Continuous Photochemical Benzyne-Forming Process 

A continuous-flow process is presented that enables the safe generation and derivatization of benzyne under photochemical conditions. This is facilitated by a new high-power LED lamp emitting light at 365 nm. The resulting flow process effectively controls the release of gaseous by-products based on an adjustable backpressure regulator and delivers a series of heterocyclic products in a short residence time of 3 minutes. The robustness of this methodology is demonstrated for the rapid generation of benzotriazoles, 2H-indazoles and various furan-derived adducts, facilitating the preparation of these important heterocyclic scaffolds via a simple and readily scalable flow protocol.

Read the full article here.

4-Cyano-3-oxotetrahydrothiophene (c-THT): An Ideal Acrylonitrile Anion Equivalent

4-Cyano-3-oxotetrahydrothiophene (c-THT) has much more to offer than just a platform to various heterocyclic scaffolds. This solid, bench-stable and commercially available reagent can be readily transformed into thioglycolic acid and acrylonitrile upon simple addition of a hydroxide anion. This interesting feature enables its use as a particularly versatile acrylonitrile anion surrogate.

Read the full article here.