Biomimetic Synthesis of Bipleiophylline
Guillaume Vincent, Erwan Poupon and Laurent Evanno describe the biomimetic synthesis of bipleiophylline.
With over 2500 described structures, monoterpene indole alkaloids constitute a class of natural substances all derived from a single common precursor (strictosidine). These compounds are fascinating both in terms of complexity and diversity and are, needless to recall in detail, of great biological value, especially in the field of pharmacology. The synthesis of such molecules represents a challenging task for organic chemists, as well as an opportunity for developing innovative synthetic methods and strategies towards the assembling of these molecular scaffolds. Indeed, several research teams worldwide still consider monoterpene indole alkaloids as stimulating targets of choice in total synthesis. Even more challenging is the access to bis-indole alkaloids of this family. Among them,
To tackle the challenge of synthesizing
Read the full article Biomimetic Synthesis of Bipleiophylline