Monitoring Solid-Phase Reactions with Thin-Layer Chromatography
Simple and Practical Real-Time Analysis of Solid-Phase Reactions by Thin-Layer Chromatography: C.-H. Wu, C. C. Chen, S.-C. Lin, C.-C. Wang
Synlett 2018, DOI: 10.1055/s-0036-1592008
Solid-phase synthesis is a practical approach for simplifying the time-consuming and routine purification steps in the preparation of numerous synthetic and naturally occurring molecules; however, monitoring such reactions is often challenging due to the lack of a convenient monitoring method. The group of Professor Cheng-Chung Wang (Academia Sinica, Taipei, Taiwan) recently reported a protocol for using thin-layer chromatography in conjunction with a photolabile linker on a resin, resulting in an efficient procedure for monitoring solid-phase reactions in real time.