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Nuklearmedizin

DOI 10.1055/s-00034924

Nuklearmedizin - NuclearMedicine

In dieser Ausgabe:

Superimposing kidneys in [99mTc]MAG-3 and [99mTc]DMSA-scintigraphy in a tricky case of an extensive, displacing growing retroperitoneal liposarcoma

[99mTc]mercaptoacetyltriglycine (MAG-3) scintigraphy is commonly used to determine split renal function before surgical intervention or radio/chemotherapy1. We present a tricky case of an extensively growing, kidney displacing retroperitoneal liposarcoma ahead and after tumour resection.

A 54-year-old patient with an extensively growing and displacing retroperitoneal liposarcoma (30 × 32 cm) was initially staged as T4 N0 M0 (UICC stage III). Following four cycles of neoadjuvant chemotherapy, R0 r...

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When Exercise Echoes: Unusual Tc99m HDP Uptake in Thigh Adductors Post-Workout

The use of Technetium-99m hydroxymethylene diphosphonate (Tc99m HDP) bone scans in nuclear medicine has been a consistent choice for decades, primarily for diagnosing skeletal issues. Even with the presence of PET scans, bone scans remain extensively used due to its cost-effectiveness, efficiency, and capability for simple whole-body assessment with high sensitivity. This agent's fundamental mechanism involves binding to hydroxyapatite crystals in the bone, effectively highlighting areas with ch...

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Determination of the optimal imaging protocol for [18F]PSMA-PET-CT for the detection of bone metastases in prostate cancer patients

Aim Prostate-specific membrane antigen-positron emission tomography (PSMA-PET) is a widely used diagnostic tool in patients with prostate cancer (PC). However, due to the limited availability of PET scanners and relevant acquisition costs, it is important to consider the indications and acquisition time. The aim of this investigation was to determine whether a PET scan from the skull base to the proximal thigh is sufficient to detect the presence of bone metastases.

Methods A retrospective analysis...

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Interobserver Agreement of visual and semi-quantitative methods in 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) imaging for risk stratification of hypofunctional thyroid nodules

Aim 99mTc-Methoxy-Isobuty-Isonitrile (MIBI) imaging is used for risk stratifications of hypofunctioning thyroid nodules (TNs). MIBI uptake in the nodular tissue is compared to the uptake in the paranodular thyroid tissue. MIBI imaging may be interpreted visually and/or semi-quantitatively. This study aimed to evaluate the interobserver agreement (IOA) of different methods of interpreting MIBI imaging (visual and semi-quantitative approaches).

Methods MIBI imaging data from 2018 to 2020 were collect...

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18F-labelled gentiobiose as potential PET-radiotracer for specific bacterial imaging: precursor synthesis, radiolabelling and in vitro evaluation

Aim Bacterial infections are a clinical challenge, requiring fast and specific diagnosis to ensure effective treatment. Therefore, this project is dedicated to development of positron emission tomography (PET) radiotracers specifically targeting bacteria. Unlike previously developed bacteria-specific radiotracers, which are successful in detecting Gram-negative bacteria, tracers capable of imaging Gram-positive infections are still lacking.

Methods The disaccharide gentiobiose as abundant part of t...

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