Background Successive multicenter studies for pediatric low-grade glioma (LGG) in Germany were accompanied by a doubling of annual recruitment over 2 decades. We investigated whether this increase conveyed a change of epidemiologic characteristics or survival.

Methods and results Participating centers reported 4634 patients with the radiologic/histologic diagnosis of LGG (1996–2018), rising from 109 to 278/year. Relating these numbers to all pediatric CNS tumors registered at the German Childhood C...

Hintergrund Gentamicin kommt in vielen pädiatrisch onkologischen Behandlungszentren in der Erstlinien-Kombinationstherapie bei Fieber und Granulozytopenie zum Einsatz. Seit 2011 verwenden wir hierzu eine Dosierung von 250 mg/m²KOF (max. 10 mg/kg, max. 400 mg) als tgl. Einmalgabe nach der deutschen Leitlinie.

Patienten und Methoden In diesem prospektiven Audit (Februar 2011 – Dezember 2019) wurden bei 66 kinderonkologischen Patienten 105 Gentamicin-Zyklen in Hinblick auf die Adhärenz zum Dosierungss...

Hereditary cancer predisposition in children and adolescents with cancer is increasingly recognized. Up to 10% of cancers in children develop on the basis of a cancer predisposition syndrome (CPS). (Zhang et al., N Engl J Med 2015; 373: 2336–2346)

The knowledge of an underlying CPS has implications for clinical decision-making for both the patient and as-yet clinically unaffected family members. It includes treatment modifications, surveillance strategies and genetic counseling and testing, among...

Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes mellitus (DM) and associated with hyperglycemia, ketosis, and metabolic acidosis. DKA and its complications are the most common cause of hospitalization, morbidity and mortality in children with type 1 DM (Wolfsdorf JI et al., Pediatr Diabetes 2018; 27: 155–177).

New-onset thrombocytopenia has been established as an important independent risk factor for multi-organ failure and mortality in critically ill patients. Th...