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Preservation of β-Cells as a Therapeutic Strategy for Diabetes

The preservation of pancreatic islet β-cells is crucial in diabetes mellitus, encompassing both type 1 and type 2 diabetes. β-cell dysfunction, reduced mass, and apoptosis are central to insufficient insulin secretion in both types. Research is focused on understanding β-cell characteristics and the factors regulating their function to develop novel therapeutic approaches. In type 1 diabetes (T1D), β-cell destruction by the immune system calls for exploring immunosuppressive therapies, non-stero...

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β-Thalassemia and Diabetes Mellitus: Current State and Future Directions

β-Thalassemia major is a congenital hemoglobin disorder that requires regular blood transfusion. The disease is often associated with iron overload and diabetes mellitus, among other complications. Pancreatic iron overload in β-thalassemia patients disrupts β-cell function and insulin secretion and induces insulin resistance. Several risk factors, including family history of diabetes, sedentary lifestyle, obesity, gender, and advanced age increase the risk of diabetes in β-thalassemia patients. ...

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DOI: 10.1055/s-014-59441

Hormone and Metabolic Research

Ausgabe 04 · April 2024Advances in Endocrinology

Editorial

259
Steenblock, Charlotte; Saber-Ayad, Maha M.; Bornstein, Stefan R. : International Roadshow: New Advances in Endocrinology and Metabolic Diseases

Review

261
Taneera, Jalal; Saber-Ayad, Maha M. : Preservation of β-Cells as a Therapeutic Strategy for Diabetes
272
Taneera, Jalal; Mahgoub, Eglal; Qannita, Reem; Alalami, Ayah; Shehadat, Ola Al; Youssef, Mona; Dib, Ayah; Hajji, Alaa Al; Hajji, Amani Al; Al-Khaja, Fatheya; Dewedar, Hany; Hamad, Mawieh : β-Thalassemia and Diabetes Mellitus: Current State and Future Directions

Original Article: Endocrine Research

279
Schepp, Florian; Schubert, Undine; Schmid, Janine; Lehmann, Susann; Latunde-Dada, Gladys Oluyemisi; Kose, Tugba; Steenblock, Charlotte; Bornstein, Stefan R.; Linkermann, Andreas; Ludwig, Barbara : Mechanistic Insights into Ferroptotic Cell Death in Pancreatic Islets
Zusatzmaterial
286
Schubert, Undine; Lehmann, Susann; Schmid, Janine; Morawietz, Henning; Bornstein, Stefan R.; Ludwig, Barbara : The Adrenal Gland and Pancreatic Islets – A Beneficial Endocrine Alliance
308
Steenblock, Charlotte; Richter, Stefanie; Lindemann, Dirk; Ehrlich, Hermann; Bornstein, Stefan R.; Bechmann, Nicole : Marine Sponge-Derived Secondary Metabolites Modulate SARS-CoV-2 Entry Mechanisms
Zusatzmaterial

Original Article: Endocrine Care

294
Toktogulova, Nurgul; Breidert, Matthias; Eschbach, Judith; Kudaibergenova, Indira; Omurzakova, Uulkan; Uvaidillaeva, Feruzakhan; Tagaeva, Bermet; Sultanalieva, Roza; Eftekhari, Pierre : Energy Metabolism in Residents in the Low- and Moderate Altitude Regions of Central Asia with MAFLD and Type 2 Diabetes Mellitus
300
Gruber, Sven; Stasi, Evangelia; Pion, Antonio Boan; Steiner, Regula; Erlic, Zoran; Bornstein, Stefan R.; Sudano, Isabella; Reincke, Martin; Beuschlein, Felix : Unawareness of Primary Aldosteronism as a Common Cause of Hypokalemia – Insights from the IPAHK+ Trial (Incidence of Primary Aldosteronism in Patients with Hypokalemia)
318
Kronstein-Wiedemann, Romy; Tausche, Kristin; Kolditz, Martin; Teichert, Madeleine; Thiel, Jessica; Koschel, Dirk; Tonn, Torsten; Künzel, Stephan R. : Long-COVID is Associated with Impaired Red Blood Cell Function
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